Cellular metabolism, stress signaling and a specific approved indication.
What to look for. Separate cellular experiments and infusion-metabolism measurements from improvements in symptoms. Forzinity’s approval is specific to Barth syndrome.
SS-31, or elamipretide, is researched for effects on mitochondrial function. The prescription product Forzinity received accelerated US approval to improve muscle strength in people with Barth syndrome weighing at least 30 kg.
Evidence in this guide: A narrow approved indication; broad healthy-aging uses are a different research question.
Read the SS-31 guide ↗Humanin is a mitochondria-derived peptide studied in cellular stress responses. Researchers examine how mitochondrial signaling changes in aging cells, including senescent human fibroblasts.
Evidence in this guide: Cellular senescence and mitochondrial-function research.
Read the Humanin guide ↗MOTS-c is a short mitochondria-derived signal studied in cellular energy regulation and metabolic adaptation. Clinic and community discussions connect it with exercise and body-composition goals; the original experiments here measured effects in cells and mice.
Evidence in this guide: Preclinical metabolic findings, with clinic and online protocols labeled separately.
Read the MOTS-c guide ↗NAD+ is a coenzyme used in energy transfer and cellular redox reactions. Wellness providers discuss fatigue and healthy-aging goals; the linked human IV pilot measured metabolites during an infusion rather than clinical anti-aging outcomes.
Evidence in this guide: Cell biology, a small human IV metabolism study and named provider schedules.
