NAD+ is a coenzyme used in energy transfer and cellular redox reactions. Wellness providers discuss fatigue and healthy-aging goals; the linked human IV pilot measured metabolites during an infusion rather than clinical anti-aging outcomes.
Research focus: Cellular energy and healthy-aging interest.
Choose a compound to open its research, documentation and calculator.
No FDA-approved drug product for this catalog material. Compounding eligibility and approval are separate questions.
Official source ↗NAD+ metabolism and precursor kinetics are different measurements; no single general IV/SC half-life is assigned.
Half-life describes concentration falling by half. It does not set a dosing interval, a storage period or a drug-test detection window.
Kinetics source ↗No validated common diluent for this exact material was established by the sources reviewed here. Component recipes do not establish blend compatibility.
Bacteriostatic water contains a preservative; plain sterile water does not. Preservative presence does not by itself establish compatibility or a mixed medicine’s usable period.
Preparation source ↗Evidence about cellular NAD biology does not establish benefits, dose or route for an NAD+ infusion or injection.
Check that a source concerns the same molecule, formulation, route and population. A study of cells, animals or a different product cannot confirm the contents of a vial.
Cell biology, a small human IV metabolism study and named provider schedules.
Grant and colleagues’ 2019 pilot followed blood and urine metabolites during a six-hour NAD+ infusion. It included eight NAD+ recipients and three saline controls. It provides early information about metabolism under that study protocol, not proof of anti-aging benefits or a validated home injection regimen.
Read the pilot’s methods and limitations ↗Other names you may encounter: Nicotinamide adenine dinucleotide.
Learn to read a study →Each entry keeps one schedule’s amount, frequency and cycle together. Community references, individual reports, clinical trials and prescription products describe different kinds of use. A missing duration or break stays marked as not reported.
Amounts describe mass in mg or mcg. Syringe units describe volume and depend on concentration. A cycle break is different from days off within a week.
Choose an option to explore its amounts, timing and cycle.
| When | Amount & frequency |
|---|---|
| Week 1 | 20 mg each time |
| Week 2 | 40 mg each time |
| Week 3 onward | 120 mg each time (240 mg/week) |
| When | Amount & frequency |
|---|---|
| Week 1 | 20 mg each time |
| Week 2 | 40 mg each time |
| Week 3 onward | 80 mg each time (240 mg/week) |
An alternative to the twice-weekly option, not additional sessions.
Eight NAD+ recipients and three saline controls; a metabolism study.
Community identifies source origin. It does not certify independent funding, medical credentials or the strength of a claim. Source types distinguish published reports, professional explanations and public discussions.
Explore reports, explanations and discussions from medical practices, researchers, suppliers and community members. The badges identify the source’s origin and evidence type.
How to read these source labels →Not an FDA-approved schedule or evidence of general wellness or longevity efficacy.
Source relationship: Commercial prescribing service.
The provider publishes twice- and three-times-weekly options for its prescribed preparation. The guide shows the amounts with route and concentration context.
Provider instructions · specific prescribed preparation
Service descriptions and proposed benefits do not establish a validated treatment or loading schedule.
Source relationship: Commercial IV and wellness provider.
The clinic describes IV session amounts and different visit patterns. Our guide separates those offerings from the small published IV pilot.
Clinic offering · supervised IV route
A peptide name and vial mass cannot determine a compatible diluent, powder displacement, storage temperature or discard date. Follow the exact product’s instructions and your pharmacist’s directions.
The injection guide concerns clinician-prescribed subcutaneous medicines; it does not establish that a research-labeled material can be injected.
Start with the formulation: dry powder, prepared solution, pen, tablet and topical product can have different instructions.
Hone’s example uses 200 mg/mL, so 0.1 mL contains 20 mg. That relationship cannot be transferred to a different preparation.
For comparison, 0.5 mL contains 50 mg at 100 mg/mL, but 125 mg at 250 mg/mL. On a U-100 syringe both volumes occupy 50 units. Units describe volume; concentration determines mass.
Use the actual dispensing label for route, concentration, storage and discard date. A multi-milliliter figure from an online article should not be interpreted as a weekly total or a suitable single subcutaneous volume without its original context.
Check documented concentration in the calculator ↓General health habits and consistent observations help you assess changes. They are not evidence that a peptide’s effects will be amplified.
Choose activity that fits your health and ability. Aerobic movement and muscle-strengthening work are part of general adult activity guidance.
CDC · adult activity ↗Use a regular sleep/wake schedule and note changes in sleep quality alongside symptoms or training.
CDC · sleep habits ↗What to record: Choose measurable goals such as day-to-day function, exercise tolerance or symptoms. A cellular biomarker is different from a demonstrated improvement in health or lifespan.
Check dates are editorial references, not a medical review certificate. Labels and evidence can change; consult the linked current document.
Hone’s two maintenance examples each total 240 mg per week: 120 × 2 or 80 × 3. This arithmetic does not establish equivalent absorption, effects or tolerability. Its published schedule is specific to its prescribing service. See the complete provider schedule ↗
IV Concierge describes IV amounts and visit frequencies, including more intensive programs and maintenance spaced weeks apart. Those descriptions do not validate self-directed loading phases or prove clinical benefits. Read the clinic’s full description ↗
Oral precursors need their own evidence. NR and NMN are not injectable NAD+, and trials measuring NAD-related biomarkers do not automatically demonstrate longer life or symptom improvement. A single “NAD dose” chart obscures those differences.
FDA reports severe chills, shaking, vomiting and fatigue after NAD+ injections, with some people needing medical treatment. These reactions were consistent with excessive endotoxins. Severe reactions should not be dismissed as an expected adjustment phase.
FDA has warned about food-grade NAD+ ingredients being used to compound sterile injections. Ingredient identity alone does not establish injectable quality or sterility. Read FDA’s compounding alert ↗
Opening values and worked examples illustrate arithmetic; they are not preparation instructions or recommended amounts. Selecting a compound labels the calculation and does not supply a dose or powder-volume correction.
Enter the documented vial mass, preparation information and target amount to see how mass and volume connect.
20 mg in an assumed final 1 mL gives 20 mg/mL. An entered 1 mg corresponds to 0.05 mL, or 5 U-100 units, with 20 theoretical portions before losses.
Estimate · assumes 1 mL added = total volume
1,000 mcg
Theoretical · before losses
0.2 mL
After 5 full doses
Illustration only · calculated value, without rounding
Saved calculations stay on this device.
Concentration = mass ÷ final volume
5 mg ÷ 1 mL = 5 mg/mLVolume = target mass ÷ concentration
1 mg ÷ 5 mg/mL = 0.2 mLU-100 markings = volume × 100
0.2 mL × 100 = 20 unitsComplete portions = floor(vial mass ÷ amount per portion).
Displayed numbers are rounded for readability; the calculation uses unrounded values.
Already have the concentration? Find the matching mL and U-100 syringe reading.
Need the concentration first? Use the Reconstitution tab.
5units
0.05 mL · 0.25 mg
0.25 mg ÷ 5 mg/mL = 0.05 mLU-100 units = mL × 100Example inputs are editable. The reading is calculated without rounding to a physical graduation.
Convert mass or liquid volume. U-100 markings always refer to a 100-units-per-mL scale.
1,000mcg
For mass → syringe volume, switch to Dosage and enter a concentration.