TESAMORELIN / PHASE 2 / 2017

Tesamorelin: what the 1 mg / 2 mg trial tested

What did a direct comparison of 1 mg, 2 mg and placebo actually measure?

Who was studied?

Adults with stable type 2 diabetes were assigned to placebo, 1 mg or 2 mg tesamorelin.

Participants
53 adults in the published report
Duration
12 weeks
Funding
Theratechnologies; author employment and consulting interests disclosed

What did the study find?

The trial found no significant between-group difference in its insulin-response endpoint or week-12 fasting glucose and HbA1c.

What should you keep in mind?

Small, short study focused on metabolic safety. It did not demonstrate equal visceral-fat reduction or superior tolerability with 1 mg. The registry lists 55 enrolled; the published report describes 53.

Why it matters

A dose comparison exists, but its endpoints do not validate the forum’s starter regimen or establish an absence of glucose risk over longer use.

ORIGINAL PEER-REVIEWED PAPER

Safety and metabolic effects of tesamorelin, a growth hormone-releasing factor analogue, in patients with type 2 diabetes: A randomized, placebo-controlled trial

Published 2017 · PMID 28617838 · DOI 10.1371/journal.pone.0179538

Publisher’s paper ↗PubMed record ↗Trial record: NCT01264497 ↗

Summary by Peptide Lit, checked against the original abstract on October 8, 2026. Read the complete paper for detailed methods and safety results. This page explains published research; it does not recommend a treatment or dose.

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